Ajay Yadav Anaesthesia Pdf Creator

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Emergency drugs used in anaesthesia • 1. KRISTINA PRADHAN INTERN • EMERGENCY DRUGS ATROPINE ADRENALINE MEPHENTERMINE EPHEDRINE XYLOCARD • ATROPINE CLASS: ANTICHOLIGERNIC DRUGS. BACKGROUND: A tertiary amine belladonna alkaloid, has a high affinity for muscarinic receptors. • ATROPINE MOA: binds competitively, preventing acetylcholine from binding to those sites Atropine acts both centrally and peripherally. Duration of action: Its general actions last about 4 hours except when placed topically in the eye, where the action may last for days • ORGAN ACTION THERAPEUTIC USE EYE Dilation of.

Pupils(MYDRIASIS) Blurring of near vision(CYCLOPLEGIA); Dry eye Ophthalmic: permits the measurement of refractive errors without interference by the accommodative capacity of the eye. Shorter-acting antimuscarinics (cyclopentolante and tropicamide) have largely replaced atropine due to prolonged mydriasis. GASTROINTESTINAL Antispasmodic Gastric motility is reduced, hydrochloric acid production is not significantly affected URINARY BLADDER Reduce hypermotility states of urinary bladder. Occasionally used in enuresis among children.
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• ORGAN ACTION THERAPEUTIC USE Heart low doses—bradycardia. (due to central activation of vagal efferent outflow-- result from blockade of the M1 receptors on the inhibitory prejunctional (or presynaptic) neurons- - permitting increased acetylcholine release. Higher doses-- M2 receptors on the SA node are blocked-- and the cardiac rate increases. (requires at least 1 mg of atropine) Bradycardia and partial heart block Secretions Sweat gland; salivary gland; lacrimal gland: Drying effect. • ATROPINISATION IN OP POISONING • ATROPINISATION - Start with 0.05mg/kg in children 0.6-2mg i.v., repeat 10-25 min.
Until atropinisation obtained.; Tachycardia D' s ' Delirium (disorientation) Drowsiness Dilated pupils (The mydriasis along with cyclopegia causes blurring of vision) Dryness of mouth Dry, hot skin • ADVERSE EFFECTS • PREPARATION Available( ampule): 1ml=0.6mg Dose: 0.01-0.02mg/kg Bradyarythmia: 0.04mg/kg Onset: 1-2 min Duration of Action: 20- 30 min(i.v) 2-3 hrs (i.m.) • ADRENALINE Class:Direct acting sympathomimetic drugs. It interact with both alpha and beta receptors. At low dose, beta effect ( vasodilatation) on vascular system predominant. At high dose, alpha effect (vasoconstriction) are strongest • MODE OF ACTION Increase contractility of myocardium( Inotropic Effect, beta1 action) Increase HR( Choronotropic Effect,beta 1 action) So, Increase In CO leads to Increase BP • ADRENALINE INDICATION ADVERSE EFFECTS CONTRAINDICATION BRONCHOSPASM CNS EFFECTS: ANXIETY, HEADACHE, TENSION, TREMOR. HYPERTHYROIDISM: INCREASED ADRENERGIC RECEPTOR ON VASCULATURE— HYPERSENSITIVE RESPONSE ANAPHYLACTIC SHOCK HEMORRHAGE: MARKED ELEVATION OF BP—CEREBRAL HEMORRHAGE COCAINE: PREVENT RE-UPTAKE OF CATECHOLAMINES— LONGER PERIOD OF TIME. GLAUCOMA(2%) PULMONARY EDEMA IN ANESTHETICS: TO INCREASE DURATION OF LOCAL • DOSING In cardiac arrest 1 mg (10 mL 1:10,000 solution) IV push every 3 to 5 minutes. If this fails, higher doses of epinephrine (up to 0.2mg/kg) are acceptable but not recommended (there is growing evidence that it may be harmful) In anaphylaxis: 3-5mcg/kg • PREPARATION Available in Ampule at concentration: 1mg/ml(1:1000) Preparation: 100mcg/ml 10mcg/ml • MEPHENTERAMINE Class: Sympathomimetic ( Mixed action adrenergic agonist) Mechanism of action: - Acts indirectly by releasing norepinephrine from its storage sites and directly by exerting a slight effect on alpha and beta-1 receptors and a moderate effect on beta-2 receptors mediating vasodilation.